Diminished interaction between mutant NOTCH1 and the NuRD corepressor complex upregulates CCL17 in chronic lymphocytic leukemia
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چکیده
منابع مشابه
Activation of the NOTCH1 pathway in chronic lymphocytic leukemia.
328 haematologica | 2012; 97(3) Figure 1. Schematic representation of the NOTCH1 receptor. The extracellular domain of NOTCH1 consists of 36 epidermal growth factor-like repeats (EGFR) followed by 3 cysteine-rich lin12/Notch repeats (LNR) and the heterodimerization domain (HD). Upon transport to the plasmamembrane, NOTCH1 is cleaved in two units, which are kept together by interactions between ...
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Background and purpose: Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia characterized by the accumulation of seemingly mature type B lymphocytes in peripheral blood and lymphatic organs. One of the main markers used in the diagnosis and prognosis of CLL is the CD38 gene. Polymorphism is considered to be a major genetic source of phenotypic change within a species an...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2019
ISSN: 0887-6924,1476-5551
DOI: 10.1038/s41375-019-0526-5